In most cases, the specific cause of Hodgkin's disease remains unknown. Every child with this diagnosis should receive treatment. Currently, modern medicine cures 87 children out of 100 with this disease.
Treatment of children with lymphogranulomatosis is a long process, it takes from 3 to 12 months and is carried out according to special protocols.
Depending on the stage of the disease , patients with lymphogranulomatosis are divided into three therapeutic groups that determine the intensity and duration of therapy: therapeutic group( TG)-1.2 and 3.
Therapy for Hodgkin's disease consists of two stages. The first stage is polychemotherapy, aimed at the maximum destruction of malignant cells and achieving remission with the help of chemotherapy drugs. The second stage is radiation therapy, aimed at fixing and long-term preservation of remission by destroying residual tumor cells, which can later cause a relapse (return of the disease).
To make a diagnosis, determine the stage of the disease, a diagnostic operation is necessary-an open biopsy of the affected lymph node to study the primary tumor, as well as a study of the bone marrow. To control the status of the disease in dynamics, in some cases, a repeated biopsy of the lymph node may be performed.
We offer you treatment using the "DAL-HD-95-m" Protocol, which is based on the German "DAL-HD-95" Protocol, with a total survival rate of 98%.
Treatment according to the Protocol consists of a stage of chemotherapy and a stage of radiation therapy.
Chemotherapy consists of consecutive treatment blocks (from 2 to 6 blocks depending on the therapeutic group).
Radiation therapy with limited radiation fields is performed in all patients on the initial lesion zones at a dose of 20 Gy. If necessary, the dose of radiation therapy is further increased by 10 g.
In accordance with the Protocol, your child will undergo a diagnostic examination before starting therapy : ultrasound, CT, PET, bone marrow puncture (CMT), trepan-bone marrow biopsy, open lymph node biopsy from the affected area.
The possible risk and complications of CMR, trepan biopsy, and lymph node biopsy are minimal. In rare cases, there may be bleeding from the injection site and local infections at the biopsy site .Open biopsy of the lymph node and CMC is performed under local or General anesthesia.
All medications used in the treatment of Hodgkin's disease in children, along with the effect on malignant cells, can cause side effects. Among them are: nausea and vomiting, temporary hair loss, effect on mucous membranes, hematopoietic organs and blood cells. There is a risk of infectious complications. In these cases, the Protocol provides accompanying therapy. Side effects of chemotherapy can also appear some time after the end of treatment, so it is very important that children are under the supervision of doctors and after the end of therapy. Chemotherapy can cause long-term side effects from the heart, endocrine disorders, fertility disorders, growth and development problems, and there is a risk of secondary tumors.
Side effects of radiation therapy : hair loss, dry mouth, skin and mucosal reactions are temporary. Radiation therapy can cause changes in organs and tissues( for example, a violation of the function of the thyroid gland, the reproductive system).Secondary tumors can develop 20 or more years after treatment.
German colleagues participated in the development of the Protocol "DAL-HD-95-" for the treatment of children and adolescents with Hodgkin's disease .It is also used in Russia . For more information about treatment, please contact your doctor.