Our scientific activities
The scientific Department of the state institution "rnpc of children's Oncology, Hematology and immunology" currently has 3 doctors of science and 22 candidates of science. The research Department offers postgraduate courses in two specialties: Hematology and blood transfusion, and clinical immunology and Allergology.
During the existence of the center, 5 doctoral and 25 PhD theses have been defended. In total, the Center (in the scientific and clinical departments) currently employs 3 doctors of science and 30 candidates of science. Among the employees of the Center, 11 people have the academic title of associate Professor, 1-corresponding member of the national Academy of Sciences of Belarus.
Main directions of scientific research:
- epidemiology of malignant neoplasms, primary immunodeficiency and hemopathies in children and adolescents;
- study of prognostic risk factors that affect the outcome of the disease, in order to stratify patients to choose the optimal therapy for each of their risk groups;
- development of a methodology for monitoring minimal residual disease in malignant neoplasms in children and adolescents;
- development of programs for the treatment of malignant neoplasms and hematological diseases in children and adolescents using cell technologies, hematopoietic stem cell transplantation, and immunotherapy;
- development of methods for graft cleaning, prevention and treatment of graft-versus-host (GVHD) reactions after hematopoietic stem cell transplantation;
- development and experimental substantiation of immunological and molecular-biological bases of primary immunodeficiency correction;
- cell biotechnologies for the treatment of neoplasms (idiotypic antitumor vaccines), liver cirrhosis (MSCS), and steroid-resistant forms of GVHD (MSCS);
- optimization of DNA diagnostics of oncological diseases.
Applied and basic research in the field of pediatric Oncology, Hematology and immunology is carried out within the framework of state programs, state and industry scientific and technical programs, and state research programs. In 2015 the Center carried out 35 projects, including the tasks of the state scientific and technical program "New technologies for diagnosis, treatment and prevention" (subroutines "Oncology" and "Transplantology and regenerative medicine"), the state research program "Medicine and pharmacy", and the branch scientific and technical programs " Healthy mother – healthy child - strong state " and "Expert rehabilitation technologies", the state program" Innovative biotechnologies "(medical biotechnology sub-program), the Belarusian Republican Foundation for basic research, as well as the Joint program to overcome the consequences of the Chernobyl disaster within the Union state.
During the period of 1998 – 2015, the Center completed 119 research projects. Based on the results of the research, more than 80 instructions on the use of new methods of diagnosis and treatment have been developed and approved by the Ministry of health. The center's staff has published more than 2,000 scientific papers, including 14 monographs, 980 scientific articles (90 of them in foreign English - language scientific journals), and 12 patents for inventions.
The center carries out international scientific and practical cooperation with:
- clinical centers in Russia;
- Children's clinic of the University of Hanover (Germany);
- Children's clinic of the University of Graz (Austria);
- The international Agency for cancer;
- French national register of solid tumors;
- University hospital of Lille (France);
- International research group on the treatment of Langerhans cell histiocytosis;
- The international BFM study group;
- International Agency for research on cancer;
- the DCAL University diagnostic center at Goethe University in Frankfurt am main (Germany).
An agreement was signed on scientific and practical cooperation with the research Institute of Hematology and blood transfusion of the Ministry of health of the Republic of Uzbekistan.
A cooperation agreement was signed with the Ural Federal University named after the first President of Russia B. N. Yeltsin.
A Memorandum of cooperation was signed with the medical school of the Tehran medical University (Iran) and the universal Scientific Education and Research network (USERN) of the Republic of Iran.
Cooperative research is conducted with CIS countries in the framework of treatment protocols: acute lymphoblastic leukemia (ALL-MB-2015, Russia-Belarus), acute myeloblastic leukemia (AML-MM-2014, Russia – Belarus), relapses of acute lymphoblastic leukemia (ALL-REC-BFM-2002, Belarus-Russia-Kazakhstan), acute promyelocytic leukemia, (Russia Belarus), acute lymphoblastic leukemia in children under one year of age (Russia-Belarus).
International cooperation is being conducted within the framework of international registers:
- "Immune thrombocytopenia of adults and children", Switzerland. European society of pediatric hematologists.
- "Severe chronic neutropenia in children", Germany, within the framework of the European-American cooperation.
- Langerhans cell histiocytosis in children, Austria
- Gaucher's disease European registry, Netherlands
Since 2012, the Center has been awarded the status of the International Center for the diagnosis and treatment of Primary Immunodeficiency. Geoffrey Modell. The Foundation unites more than 50 Centers for the diagnosis and treatment of primary immunodeficiency, mainly in Europe and the United States.
The relationship between the National Register of Primary Immunodeficiency of the Republic of Belarus and the European Register of Primary Immunodeficiency is supported.